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Currently, a 52-week Phase 2 clinical trial (NCT05669599) is underway for the overweight and obese population to further evaluate the safety and long-term efficacy of AMG133

Somatopause is a gradual and progressive decline in HGH secretion that occurs normally with aging and is associated with increased adipose tissue ( Several mutations that impair the somatotropic axis have been associated with increased lifespan in mice

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Extensive clinical research, particularly in the context of insulin resistance and polycystic ovary syndrome (PCOS), has demonstrated that supplementing with this exact 40:1 ratio is the most effective way to restore systemic metabolic health without causing unintended side effects