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However, in chronic tendinopathy, its efficacy may be compromised due to persistent inflammation, tissue degeneration, fibrosis, and abnormal ECM composition, which can impede IGF-1 diffusion and diminish the responsiveness of tendon cells (Tang et al., 2024)

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Adolescents aged 1114 years require 1.2 g, increasing to the adult dose of 1.5 g from age 15 onwards