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The definitive 24-week Phase III trial in 534 obese participants, testing doses of 0.25mg, 0.5mg and 1.0mg daily, did not produce statistically significant weight loss over placebo

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COPD In COPD, it has been reported that NPY expression is decreased in the lung epithelium, glands and smooth muscle tissue [171], and the authors speculated that such changes might contribute to COPD pathogenesis

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