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Once glutathione oxidizes to GSSG, it stays oxidized

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Overexpression of glutaredoxin protects cardiomyocytes against nitric oxide-induced apoptosis with suppressing the S-nitrosylation of proteins and nuclear translocation of GAPDH

Main pathway: G-actin sequestration Native T4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 M, controlling the pool of free actin available for polymerization into F-actin (actin filaments)

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