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Pantothenic acid alleviates osteoarthritis progression by inhibiting inflammatory response and ferroptosis through the sirt1/nrf2 signaling pathway

Compound 102 exhibited overt suppression of ROS accumulation in a dose-dependent manner with an EC 50 of about 11.4 M (fluorescent intensity determined by ImageJ and a plate reader, Supplementary Figures S7 , S8 )

Kumbrink J, Gerlinger M, Johnson JP

A., Bennett, J., Jarzynka, M

With the treatment time as the horizontal coordinate, the tumor volume and the mouse body weight as the vertical coordinate, the tumor growth curve and the mouse body weight change curve were plotted respectively

X., McCormack W