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A key contributor to this dysfunction is mitochondrial dysfunction, characterized by defective oxidative phosphorylation, impaired adaptation, and depolarization, which promotes T cell exhaustion and severely compromises antitumor efficacy

Lancet 379(9822):125668

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Mar 14 2020;18(1):22

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Its made up of three important building blocks called amino acids: cysteine, glycine, and glutamine