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Moreover, an upregulation of HMOX1 favours the accumulation of Fe 2+ that can react with H 2 O 2 in a Fenton-like reaction thus producing the highly reactive ROS hydroxyl radical

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Key roles of glutathione include: Antioxidant defense - neutralizes reactive oxygen species that damage DNA, proteins, and cell membranes, as documented in research on the Past and Present of antioxidant studies spanning multiple decades Toxin clearance - binds to heavy metals, pollutants, and drug metabolites so they can be excreted in urine or bile Immune balance - supports T cells and other immune cells that respond to infections and inflammation Mitochondrial protection - guards the energy-producing machinery in cells from oxidative damage Cell repair and turnover - influences cell growth and programmed cell death ( apoptosis ) Glutathione levels tend to decline with: Age Chronic stress and poor sleep Environmental toxin exposure Chronic illness and ongoing inflammation That decline is linked to neurodegenerative conditions, immune dysregulation, and respiratory disease, which is why so many people look for effective ways to support glutathione

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Ethics statement Ethical approval was not provided for this study on human participants because FAERS (FDA Adverse Event Reporting System) is publicly available and anonymous database, so approval and written informed consent were waived by the ethics review board of the Ethical Committee of West China Second University Hospital of Sichuan University