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Screening followed PRISMA guidelines (titles/abstracts, then full text) to ensure transparency and reproducibility

doi: 10.3390/ijms24108643 10 European Medicines Agency (2024)

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Safety data in special populationssuch as pregnant or lactating women, pediatric patients, and those with advanced renal or hepatic impairmentremain limited and require further study

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Many studies suffer from small sample sizes, short durations, or lack of proper control groups, making it difficult to separate genuine effects from placebo responses