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The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

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Animals were not used for multiple experiments as two of the three experiments were non-survival (due to the blood collection following DMRS and the urethane anesthesia used for fMRI) and incompatible (DMRS and PET both required labeled glucose injection, the DMRS and fMRI signals may interfere with each other, and fMRI required different anesthesia than the other two experiments)

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