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Other oral medications may come with their own set of side effects
For example, iron ions cannot only act on the gastrointestinal mucosa, causing gastrointestinal damage, but also severely damage hepatocytes, causing lipid peroxidation, cell swelling, and tissue necrosis, leading to liver fibrosis or liver cancer (Jang et al., 2014)
Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney
Ongoing research continues to explore its potential applications in nonalcoholic fatty liver disease (NAFLD), where a 2019 trial published in Lancet HIV demonstrated a 32% relative reduction in hepatic fat fraction over 12 months
