Animal pharmacokinetic data for subcutaneous and intraperitoneal injection exist within the body of work from the Zagreb group and a smaller number of independent labs
Furthermore, by causing apoptosis and fibrosis, reactive oxygen species and inflammatory cytokines might harm renal tissue 32
Furthermore, another study identified that the Ptges2 gene elevates the risk of tendinopathy by downregulating the expression of Cox2 [18] and promoting the production of prostaglandin H2 (PGE2), a signaling molecule implicated in tissue degeneration and inflammation
The practical difference for most people is minimal, though methylcobalamin skips the conversion step and may be preferable for individuals with certain genetic variations affecting B12 metabolism
Diabetes Care, 22(2), 280-287
No matter which supplement you try, it's a good idea to check with your doctor first