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Do not attempt to increase your dose or lower it without proper advice from a health care professional

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doi:10.1080/10408398.2018.1552244 258

Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants

It's ideal for patients experiencing a plateau or considering dose escalation, as it clarifies whether genetic factors or lifestyle adjustments should drive your next treatment change

We speculate that this paradoxical result may be due to the complexity of the causes of diabetes itself and the disorganized gut flora of obese populations that cannot interact well with RS