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According to FDA prescribing information, these effects are typically most pronounced during initial treatment and after dose escalations, often improving over time as the body adjusts

(27) The study demonstrated that GLP-1 use was associated with a significantly lower risk of DFU compared to insulin (HR: 0.44, 95% CI: 0.320.60) for short-term use (400 days) and long-term use (HR: 0.74, 95% CI: 0.600.92)

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