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Above a cytotoxic threshold, ROS-induced oxidative stress (OS) would be detrimental to cancer cells and lead to apoptosis or senescence

Of significance and supporting a potential anti-cancer action of metformin is that LKB1 is a tumor suppressor and that mutations in LKB1 are observed in numerous cancers that result in the reduction of the inhibitory effect of the LKB1/AMPK pathway on the pro-proliferative signaling via mTOR (125, 126)

Acknowledgements All the figures in the manuscript were drawn by Figdraw

Many feel they are doing all the right things yet not seeing the results, perhaps due to a combination of, eating too much, low metabolism, stress, lack of sleep and other lifestyle factors

10.3389/fnins.2016.00080 18 FryeR