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ENT-01 ( squalamine phosphate ) inhibits -synuclein aggregation in the gastrointestinal tract and significantly increased the number of complete spontaneous bowel movements per week after 25 days on ENT-01 treatment in a double-blind, placebo-controlled, phase 2b RCT in 150 participants with PD and constipation however at the expense of gastrointestinal AEs in up to one third of participants [166]

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Some people also find that certain amino acids in collagen, like glycine, have a calming effect that supports a restful evening

doi: 10.1210/endo.133.1.8319572 47 DamholtABBuchanAMKofodH

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