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Since 2010, it has technically remained the only truly FDA-approved treatment specifically indicated for the treatment of chronic migraine prevention, up until Qulipta (Atogepant) became the first and only pill to receive FDA approval for chronic migraine in 2023

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X-ray crystallography and NMR spectroscopy have established that copper coordinates through a 3N1O equatorial square-planar pyramid configuration: the histidine imidazole nitrogen, the glycine -amino nitrogen, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, with additional oxygen coordination from neighboring complex carboxyl groups

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