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It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated

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Zinc also plays a key role in regulating the function of MMP2 and MMP9 named gelatinases whose expression increases during inflammation with artery damage

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During OA, synovial tissue exhibits an inflammatory response, releasing IL-1, IL-6, TNF-, and other cytokines and chemokines that attract peripheral immune cells such as macrophages, neutrophils, and T cells to the synovial membrane (145, 146)

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