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Historically, peptides were first isolated in the early 20th century, with insulin being one of the most notable discovered in 1921 and later synthesized as a treatment for diabetes

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Han K, Jia N, Li J, Yang L, Min L (2013) Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimers disease