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Exercise considerations Exercise during semaglutide therapy preserves lean muscle mass, which is critical during rapid weight loss

Investigators are also studying its effects on hepatic fat (MASLD/MASH), cardiovascular risk markers, and obstructive sleep apnea areas where appetite suppression alone cannot fully explain the observed improvements

Neuroinflammation or fever is presumed to also trigger ISR, as autoantibodies may target neural or immune systems and cause inflammation elsewhere (418)

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Medical contraindications include personal or family history of medullary thyroid cancer, MEN2 syndrome, or severe pancreatitis

In this video, learn what might be causing it