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Contribution of GLP-1 to changes in reward behavior after bariatric surgery Bariatric surgery results in an impressive weight loss, reduced food intake and a lack of compensatory energy expenditure reduction (le Roux and Bloom, 2005

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[33] Gut-brain axis modulation Insulin dysfunction is closely linked with disturbances in gut hormones (GLP-1, leptin, and ghrelin) and gut microbiota composition

[8] When administered, they bind to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

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Doses as low as 10 g had a beneficial effect on post meal glucose excursions and there was no evidence of glucagon-induced hyperglycaemia (82)