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A 2025 IV safety study in two healthy human volunteers administered doses up to 20 mg without adverse events the highest quality human safety data currently available, but from only two subjects

Reserve purely systemic injection for situations where local access is difficult or when addressing multiple widespread issues

Muscle weakness or bone pain from overcorrection

While side effects are generally mild and temporary, they may include redness or soreness at the injection site, a temporary "flushed" feeling, or brief lightheadedness

Duration of Treatment and Maintenance Phase Treatment for moderate neuropathy with B12 can last 3-6 months

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