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Sobo, the emphasis is on medically guided care
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Short-chain fatty acids (SFCAs) like acetate, butyrate and propionate, derived from host microbial fermentation of non-digestible carbohydrates, transduce signals through GPCR to promote anti-inflammatory cytokines (IL-10, IL-18) and Treg responses [198, 199] These SCFAs also suppress pro-inflammatory histone deacetylase (HDAC), NF-B and nitric oxide production, thus diminishing oxidative stress-induced epithelial cell apoptosis, and exerting a protective effect on colonic and cardiac health [199]
In addition, while some patients have generalized deficiencies, thiamine deficiency seems to be the main culprit of severe symptoms
Maintain adequate caloric intake through small, frequent, nutrient-dense meals, ensure proper hydration (68 glasses daily), prioritise protein-rich foods, and engage in regular light physical activity
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