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A key finding was its ability to reduce phosphorylation of myosin light chain-2 through inhibition of the ROCK pathway, a central regulator of perijunctional actomyosin contraction and barrier leakiness

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METAOD005: A Phase IIb (randomized, double-blind, placebo-controlled) study to assess the efficacy (reduction in body weight), safety and tolerability of 12 weeks treatment with daily doses (1, 5, 10, 20 or 30 mg AOD9604) administered orally (capsules) in 300 healthy, clinically obese males, and females of non-child bearing potential, with a BMI 35 kg/m 2