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H3R-KO mice were shown to consume more food and have an increase in body weight from approximately 10 weeks of age (127)

TMAO increases renal fibrosis: evidence from an intervention in male mice To corroborate our in vitro findings suggesting that TMAO directly increases myofibroblast trans-differentiation and establish in vivo relevance, we performed Unilateral Ureter Obstruction (UUO) surgery in mice, a model assessing renal fibrosis in the absence of other co-morbidities 51 that could be also impacted by TMAO

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