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Epinephrine can be considered in refractory cases, while pure -agonists such as phenylephrine are usually avoided because they increase RV afterload

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GHK-Cu timing matters less for systemic effects, though evening administration may support overnight regenerative processes

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Symptomatic magnesium deficiency remains relatively uncommon, but awareness of potential risk factors allows for appropriate clinical vigilance, particularly in patients with persistent gastrointestinal symptoms or those on multiple medications affecting mineral balance

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