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doi: 10.1002/jps.21924

Over-supplementation of B12 Vitamin B12 is a water-soluble vitamin, and excess amounts are generally excreted rather than being stored

Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12

doi: 10.1073/pnas.1412271111

Some patients report improvements in sleep, recovery, or energy within weeks, while others experience more gradual changes