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It is important to note that drugs like NSAIDs and steroids can have long-term detrimental effects on knee OA, accelerating degeneration

JCI Insight 5 , e132747 (2020)

SS-31 addresses the cellular energy consequences Who May Not Be Ideal Candidates Patients expecting immediate dramatic results: SS-31s benefits are cumulative and gradual patients who need immediate energy relief may respond better to NAD+ IV therapy as a faster-acting energy intervention while SS-31 builds longer-term mitochondrial support Patients with budget constraints requiring a single peptide: if only one mitochondrial peptide is in budget, NAD+ typically provides a broader immediate energy response

10.1002/jssc.201900222 20 DengP

Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in Type 2 Diabetes