"There are allowances for doctors to make their own decisions, backed up by robust evidence to prescribe unapproved products to their patients," TGA chief medical adviser Robyn Langham told Four Corners
The effects of semaglutide on kidney oxygenation, albuminuria and eGFR will be assessed in people with type 1 diabetes as part of the REMODEL-T1D mechanistic trial (NCT05822609)
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It enhances mitochondrial biogenesis and improves electron transport chain efficiency, protecting against complex I inhibition and electron leakage
Semaglutides trade-offs are cost, gastrointestinal side effects, contraindications including medullary thyroid carcinoma history, and the need for careful titration
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