Long-term controlled safety data are absent
It also depends on how the numbers are measuredclinical trials report weight loss using different estimands (essentially, different ways of calculating average results), which is why youll sometimes see slightly different percentages for the same study
Burgos N, Toloza FJK, Singh Ospina NM, Brito JP, Salloum RG, Hassett LC, et al
doi: 10.1186/s13071-018-3043-x 20
The scientific studies of these experimental drugs were never large enough or long enough to establish a clear safety profile, so all we are left with are vague reassurances from tiny studies and testimonials from YouTubers and TikTokers
Liu et al., 2017) The loss of these pro-survival factors disrupts the balance between anti-apoptotic and pro-apoptotic signaling, increasing granulosa cells susceptibility to apoptosis