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Further, the phosphorylation mechanisms identified are consistent with convergent effects of Agm with its co-transmitter Glu on canonical LTP pathways

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To assess the effects of BHBA on intracellular Ca 2+ levels, hippocampal neurons were loaded with the calcium-sensitive fluorescence indicator Fluo-4AM, and the changes in fluorescence intensity were measured in all cell bodies of neurons (Figure 3A)

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Elevated NNMT activity has been associated with obesity, insulin resistance, and reduced metabolic efficiency