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To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed

PMID: 17317455

138 SIRT5-mediated IDH2 desuccinylation also regulates cellular NADPH homeostasis and redox potential

Miller BA, Kolonel LN, Bernstein L, Young JL, Swanson GM, West D, Key CR, Liff JM, Glover CS, Alexander GA, et al

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Genetic knockdown or pharmacological inhibition of ACSL4 can partially ameliorate lipid peroxidation-induced chondrocyte damage and slow OA progression (7577)