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Combined therapy that involves the inhibition of Gln metabolism alongside PD-L1 blockade has been shown to enhance the anti-tumor immune response of T cells ( in vivo and in vitro ( DON, which exhibits high structural similarity to Gln, enhances the cytotoxic effects of CD8+ T cells while inhibiting Gln metabolism in cancer cells

Richter RW, Portenoy R, Sharma U, Lamoreaux L, Bockbrader H, Knapp LE

10.1042/bj3230159 188 LiuJ.Garcia-CardenaG.SessaW

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Rather than pushing intake higher, protein helps meals feel more complete and steady