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Despite the thermodynamically highly favorable reverse reaction, PfGrx C88S (S 2 ) reacted very slowly with roGFP2 WT (SH) 2 most likely due to the instability and high energy of the Grx(SSR) intermediate

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Comment: The applicant reiterated that the LithoVue TM Elite Ureteroscope is a single-use ureteroscope, is not subject to capital equipment depreciation schedules, and is therefore not excluded under the criterion at 419.66(b)(4)