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[DOI] [PubMed] [Google Scholar] 15.Caturano A., DAngelo M., Mormone A., Russo V., Mollica M.P., Salvatore T., Galiero R., Rinaldi L., Vetrano E., Marfella R., et al

It is often considered by individuals with active lifestyles, those focused on gastrointestinal wellness, or anyone following a practitioner-guided recovery protocol

The Gradual Introduction Protocol Rather than starting at standard doses, begin with minimal exposure and increase slowly

Additionally, anyone with existing health conditions should speak with a professional before use

Users with established tolerance who haven't achieved desired results at 1% may benefit from stepping up to 2%

(1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction