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Peripheral immune system activation, particularly involving monocytes and macrophages, can contribute to central nervous system inflammation through various mechanisms, including bloodbrain barrier disruption and activation of neuroinflammatory pathways

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Additionally, an imbalance in the w-6:w-3 ratios is associated with maternal postpartum depression (PPD), suggesting that addressing the competition between w-3 and w-6 could be a therapeutic approach for treating depression (320)

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Chronic low-grade inflammation, increasingly recognized as a contributor to numerous age-related health conditions, may be partially mediated by inadequate antioxidant defenses including suboptimal glutathione status

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