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Alteration of ion homeostasis is also observed, together with the induction of HIF1 signaling and oxidative stress (Martins Gomes et al., 2019)

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Hepatic overexpression of SIRT6 inhibits intestinal cholesterol and fat absorption and reduces very low-density lipoprotein secretion, providing protection against steatohepatitis and atherosclerosis induced by a Western diet in Ldlr / mice [14]

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