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10.1016/j.jes.2025.01.001 211 ZuppiniF.RenzulloL.TornatoreF.PoggioP.BrancaccioM

The hepatotoxicity of APAP rests predominantly with the highly toxic and reactive compound NAPQI, which forms covalent bonds with sulfhydryl groups on cysteine and lysine molecules within the mitochondria of hepatocytes and which spontaneously reacts with GSH and binds to hepatic proteins

Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells

This description provides an overview of its current research status and applications within academic and pharmaceutical investigations

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Extensive research has highlighted the critical role of the gut-heart axis [93]