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First, as adjuncts to standard care, selected strains or formulationssuch as Escherichia coli Nissle 1917, VSL#3, and certain multi-strain probioticsprovide additive or synergistic benefits, improving key outcomes including clinical response, endoscopic remission, and health-related quality of life (HRQoL

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10.1016/j.jad.2023.04.003 242 KiriyamaY.NochiH

Additionally, this study underscores the need for clinical approaches that address both the toxicological aspects and modulation of the inflammatory response to improve patient outcomes