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Combination of PIO with TOFO also suppressed oxidative stress (urinary 8-hydroxydeoxyguanosine) and cytokeratin-18 fragments (molecules that are essentially involved in the pathogenesis of NASH) vs

Consistent with this, we observed transcriptional alterations in cholesterol-associated genes and enrichment of cholesteryl esters in OVCA ascites, supporting a role for sterol metabolism in the ascites response

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