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In recent years, we have witnessed a paradigm shift in cardiometabolic medicine: The SELECT trial demonstrated that GLP-1 receptor agonists reduce cardiovascular events even in patients without diabetes

This is also why many people regain weight after dieting

Phase 2 trial results by dose (48 weeks) Phase 3 TRIUMPH-4 results (68 weeks) The phase 3 TRIUMPH-4 data, released in early 2026, confirmed and exceeded the phase 2 results

On the other hand, numerous studies have proven the similarity of molecular mechanisms in various brain pathologies

Ellingsgaard H, Hauselmann I, Schuler B, et al

However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer