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In preclinical rat models of STZ-induced DN, PW507 demonstrated significant efficacy in alleviating mechanical allodynia and thermal hyperalgesia following acute and chronic (2-week) administration without inducing tolerance and visual evidence of toxicity

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Some individuals receive a single infusion, while others follow multi-session protocols spaced over days or weeks

Chang JY, Komaki R, Welsh J, Gomez D, Roth JA, Swisher SG