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People with higher oxidative stress loads (smokers, heavy pollution exposure, high-stress lifestyles) may take longer to see visible changes

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The activation of the cGAS-STING pathway has been confirmed to mediate the progression of synovitis and joint destruction by promoting the migration and invasion of fibroblast-like synoviocytes (FLS) and the production of inflammatory factors [22, 46]

Tablet or chewable supplements also can contain sugar (most gummies are loaded with it), and many provide minimal or no vitamin C benefit to the consumer