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An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)
Is scar revision worth it
2018;2:e00034
Yes, but oral use is typically better suited as a complement, not a substitute, for direct administration methods like injections or IV
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