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The effects can obviously differ from one drug to another

Nat Rev Neurosci (2007) 8(2):12840

(44) reported that the half-maximal effective concentrations (EC50) of GIP with GIPR and of GLP-1 with GLP-1R are 20 pM and 28 pM, respectively, without exhibiting cross-reactivity

GLP-1 drugs strengthen those natural stop signals

The MD simulation output data were evaluated based on RMSD 41 , RMSF, SASA, Gyration radius 42 , and the average number of H-bonds, with the results summarized in Table 2 and Fig