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GLP-1 is really good at its job

& Pratley, R

The associated SNP, rs10305420, is a missense variant in the signal peptide of the GLP1R gene, changing the seventh amino acid from proline to leucine (p.Pro7Leu)

There's little evidence that GLP-1 patches work at all, let alone better than clinically approved weight loss injections

Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly semaglutide 2.4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial

While on the medication, people often describe a quieting of food noise, the constant mental hum of negotiating cravings and thinking about the next opportunity to eat