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The fixed post-translation modification (PTM) was carbamidomethylation of cysteine (C), while the variable modifications included acetylation of protein N-terminus, deamidation of asparagine (N) and glutamine (Q), and oxidation of methionine (M)

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[6] Concomitant use with oral anticoagulants such as warfarin may enhance anticoagulation and alter international normalised ratio values, so prothrombin time should be reviewed more frequently following dose changes of either drug

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