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One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF

Interleukin-1

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a single session can reduce light marionette lines, for example, but might not be sufficient to gloss over more wobbly neck folds

The expiration date on the vial is there for a reason

When the effects of the drugs on pregnancy are better studied, we could learn about other contributing factors