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In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration

10.1152/ajpheart.00731.2016 44 PezelT.ViallonM.CroisilleP.SebbagL.BochatonT.GarotJ.et al (2021)

Clinical Update 1/16/2021 Coffee and Prostate Cancer Risk Is drinking coffee associated with prostate cancer risk

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For a more detailed description of contrast normalization and Gaussian blur, see Supplementary Material and figure legends