Am J Respir Crit Care Med 167 : 395399 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP 2009 Innate immunity against bacterial infection following hyperoxia exposure is impaired in nrf2-deficient mice
Together, they create an environment optimized for both repair and enhancement
The large, dimeric enzyme operates through a FAD cofactor and two essential cysteines, one of which is proximal to the glutathione disulfide docking site and the other to the FAD cofactor [129]
[DOI] [PMC free article] [PubMed] [Google Scholar] Beck GCh, Brinkkoetter P, Hanusch C, Schulte J, van Ackern K, van der Woude FJ, Yard BA (2004) Clinical review: immunomodulatory effects of dopamine in general inflammation
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Several factors can speed up glutathione depletion