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Some people tolerate semaglutide poorly even after months of use

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Originally, GLP-1 receptor agonists were licensed for the treatment of type 2 diabetes

Since the 5 -reductase-1 activity is 3 to 4 times greater in malignant than in benign prostate tissues, while the 5 -reductase-2 activity is similar in these 2 diseases 91 , whether inhibition of both isozymes by combination of specific type 1 and type 2 inhibitor or using dual inhibitor is more effective in the prevention and therapy of prostate cancer is an interesting strategy and remains to be determined

This has led to research interest in whether stimulating GH production through physiological rather than exogenous means could restore some of these functions